I’m guessing a lot of people are going to say Illustrator or Inkscape. Are there any raster art programs?
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Most are mouse first programs. Developers know that a majority do not own a pen tablet or something similar. There’s a reason why brushes in programs have smoothing, so that you can get nice curves even with a mouse.
Moreover, I would call GIMP’s experience with pen tablet relatively worse than using a mouse.
The reason why pen tablets are better in most cases is that you can use real drawing skills within those programs, like pressure and tilt, which cannot be achieved by a mouse.
Autodesk sketchbook works pretty well when using a mouse.



