• @N0t_5ure@lemmy.world
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    1415 days ago

    While I appreciate the sentiment, it really isn’t possible or even desired. What we know about genetics is like the volume of water in the Great Lakes, and what we don’t know is comparable to the volume of water in the world’s oceans. While it seems like we know a lot, we really know very little, almost nothing in comparison to what we don’t know.

    Take sickle cell anemia. The disease is a recessive trait, and both parents have to be a carrier in order for the disease to occur. It is believed that carrying one gene for the trait improved resistance to certain parasites, and thus an evolutionary advantage, allowing the gene to spread. To eradicate the disease with crispr, you’d have to eradicate it from all of the carriers, which could have the potential for negative consequences.

    In addition, in order to eradicate all genetic diseases, you’d have to genetically test everyone, even those who don’t want to be tested because they are reasonably concerned about their privacy. Moreover, what if a sickle cell (or other disease) carrier, who is perfectly healthy, doesn’t want to have their genome edited? Do we force it on them, or just sterilize them so that they cannot breed? Obviously there are some serious ethical considerations.

    Further, crispr is not perfect. There can be off-target effects. The use of it may be warranted when an infant is going to die anyway, but what about scenarios where the issue isn’t fatal? There is always a risk of introducing an unintended genetic defect, and widespread use greatly increases that risk.

    Again, reducing devastating disease is a laudable goal, but we’re just hairless apes tinkering around with the building blocks of life, and don’t know near enough to eradicate genetic disease.

  • @Donjuanme@lemmy.world
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    815 days ago

    Holy fuck this is a terrible idea.

    The child was “saved” in that they can last longer until they’d die without a liver transplant.

    It was successful because of how easy the liver is to target with medications.

    “Fixing” one organ doesn’t change the entire bodies genotype, female sex cells will continue to (potentially) carry the defect.

    These genetic “diseases” are not all without any benefit, the most common example is sickle cell anemic people have higher resistance to malaria.

    There’s no telling how “fixing” things generically will alter other systems in the body, it was done to one organ to a briefly observed window of success, that’s barely more than anecdotal evidence.

    This is what I came up with in 5 minutes, I’m not a geneticist.

    • @Sackeshi@lemmy.worldOP
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      015 days ago

      We could use gene editing to get the DNA of an organ and use it to clone a copy inside a pig for example and then use it for the patient.

      While I know someone have benefits being a carrier in the west has zero benefits. People should at least be able to sign up to be test subject if they have a chronic or terminal illness

  • @Coyote_sly@lemmy.world
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    615 days ago

    This can’t be serious. We can’t even get people to take vaccines to the point that we’re busy UN-eradicating diseases.

  • @Robotunicorn@lemmy.world
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    015 days ago

    I’m with ya, but then how will big pharma profit off these diseases? This is why we can’t have nice (life enhancing) things.