A gel injected into the scrotum could be the next male contraceptive::Biotech company Contraline has safely implanted a sperm-blocking hydrogel in 23 men. It’s designed to be a fully reversible vasectomy.

  • @HelixDab2@lemm.ee
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    771 year ago

    This kind of thing pops up repeatedly. There’s some big, splashy news about a male contraceptive, and then it flames out, or ends up being vaporware.

    The problem is that you need to stop a few million sperm with every single ejaculation; reducing that number by 99% means that you’re still risking pregnancy. Severing the ductus deferens (a vasectomy) means no sperm get through; trying to clip or block them means that some can potentially get through. Hormonal BC has the same issue; while it significantly reduces sperm count, it may not eliminate it entirely. (And there can be some really significant negative side effects from eliminating endogenous testosterone production, since hormonal levels need to be pretty far out of whack before there’s a really big cut in sperm production.)

    OTOH, women have to stop two eggs per month, or stop them from being implanted in the uterine wall. A 99% reduction in fertility for women means that it’s very, very unlikely that they’re going to be able to get pregnant.

    (Yes, women suffer from hormonal BC as well, but some women need it just to be able to live normal lives. It’s overall less of a problem than it ends up being for men. And women have the option of an IUD as well.)

    Personally, I’m in favor of vasectomy; it’s allowed me to avoid having any children for 20-odd years now.

    • @TIMMAY@lemmy.world
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      221 year ago

      Ive also avoided making kids for the last decade or so but I was born with personality-based contraceptives so I dont know that it counts

    • @frezik@midwest.social
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      101 year ago

      The problem I’ve read with Vasalgel is that they had trouble getting enough voulenteers to test it. Trials are dragging out. It does appear to work otherwise.

      I was holding out on it for a while, but ended up getting a vasectomy.

      • @HelixDab2@lemm.ee
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        21 year ago

        I thought that it, and the vasclips, had both failed in the larger clinical trials at achieving birth control rates that were even on par with hormonal BC. This is what I’m remembering from like seven or either years ago though (and internet search is such garbage now that I don’t know if I could find the sources I’m remembering).; there might be a different formulation now, or something.

    • @Shou@lemmy.world
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      61 year ago

      You are comparing sperm count and egg count as if the amount it an issue. For eggs not to be released, you end up nuking estrogen production. Hormonal BC for women is a lesser evil when comparing it to unwanted pregnancies and health conditions like endo, but you are underestimating just how bad constantly taking the pill for women is.Vasectomy is the way.

      • @HelixDab2@lemm.ee
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        11 year ago

        You are comparing sperm count and egg count as if the amount it an issue

        That’s because it is. If you have a 95% reduction in number of eggs, then your odds of pregnancy are very, very low. If you have a 95% drop in sperm count, then it’s still pretty easy for a woman to get pregnant.

        Yes, taking hormonal BC is pretty bad for a number of women. OTOH, it’s a life saver for some women, like the ones that have 3.5 week periods. For women that experience adverse side effects from hormonal BC, I’d suggest IUDs. For the very, very small number of women that neither IUDs nor hormonal BC work for, I’d suggest using condoms, and avoiding states run by Republicans.

        For men that aren’t sure, I would always suggest vasectomy first, or just learn to be gay (since it a choice, dontcha know, /s). If you end up changing your mind, be a foster parent.

    • @Syntha@sh.itjust.works
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      21 year ago

      From what I understand the problem with Vasagel isn’t it’s efficacy but with the reversibility. You can remove it from the tubes easily but the sperm might not perform as before.

    • @Mojojojo1993@lemmy.world
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      -221 year ago

      Unfortunately no. The issue is. I worked under my supervisor that has been at the forefront of this tech for years.

      The issue is men refuse to get the injection or any contraception that has side effects. Time and again the biggest obstacle for both men and women was that the procedure was not 100%.

      Therefore the side effects could be permanent. Same as women but for some unknown reason both men and women were not happy to take the risk with a sperm reduction system that could fail in 2 ways.

      It doesn’t stop sperm or it doesn’t stop stop sperm. The risks were too great that it wouldn’t be reversible or it wouldn’t be as effective as condom or pill. Both bring 99%.

      • @tsonfeir@lemm.ee
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        91 year ago

        They should be offered the opportunity to freeze their sperm at no cost if they have the vasectomy, as an insurance policy. Then the risk is null.

            • @Mojojojo1993@lemmy.world
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              51 year ago

              So they can extend it but the quality will be reduced and likely I won’t be able to have kids. It was already pretty shot due to surgical trauma. Likely I just won’t be able to sire children.

              Probably best for the world in that case

            • @tsonfeir@lemm.ee
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              41 year ago

              I eat lots of stuff after the expiration date and I’m just fine. However, that’s probably not the best analogy to use when we’re talking about spermcicles.

  • Jo Miran
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    311 year ago

    A vasectomy in my twenties was the best decision I ever made.

    10/10, would snip, tie and burn again.

      • @Furbag@lemmy.world
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        21 year ago

        It’s not really a big loss in my own personal experience. I kept hearing about reversible male contraceptive technologies “just on the horizon” from my early 20’s and I would have preferred getting a reversible procedure if such a thing had been available sooner, but when I turned age 35 and this tech still hadn’t seen the light of day, I asked myself if it being reversible was really such an important factor. I knew by that point that I never wanted to have any kids, and any future partner I would be with would need to be on the same page as me at a minimum, so I just went ahead and got it done while I was still in my sexual prime so I could enjoy the years I have left.

  • @TheWonderfool@lemmy.world
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    191 year ago

    It looks promising, even though it is quite far away from becoming available to the general public.

    Still I wish that there was more of a push for something like a contraceptive pill for men. It feels like it has been ignored for years and only now they are starting a bit with development and trials…

    • @remotelove@lemmy.ca
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      1 year ago

      I don’t think it’s been ignored. Birth control pills for men would be a massive money maker. (Here is a recent article I found on BC for men: https://www.nih.gov/news-events/nih-research-matters/male-contraceptive-disables-sperm)

      While I am speaking way outside my confort zone here, it seems magnitudes harder to effectively disable millions of sperm and their associated production as opposed to simply knocking a woman’s hormone balance a little out of whack to prevent ovulation.

      The bigger question is being ignored though: If we have to inject our scrotum with a gel, where are we going to store our pee???

    • @Kanzar@lemmy.world
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      111 year ago

      Unfortunately there has to be almost no side effects for almost all users, as there are no (as yet) medical benefits to male contraception.

      In women, not being pregnant can prevent death for some of them, regulate painful periods, etc. - it is considered the risk of the myriad side effects is worth it because at least it does some good.

      For men, who do not become pregnant, not being able to get someone else pregnant is not a medical benefit for the man.

      And unfortunately hormonal modification does cause problems. Lots of them.

  • TWeaK
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    151 year ago

    This isn’t exactly new. Vasalgel offers a similar injection that blocks the tubes, however before then back in the early 2010’s there was also a guy in India testing a better version which did not block the tubes - the compound was polarised, and when the sperm went through it was disoriented such that it couldn’t swim to the egg. The human clinical trials had a 100% success rate at preventing pregnancy, albeit human trials tend not to have that many people (I think there were 26). My understanding is that this became Vasalgel because the pharmacuetical industry didn’t like the fact that it completely avoided the complications that can come with vasectomies where the tube is completely blocked.

  • @Imgonnatrythis@sh.itjust.works
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    151 year ago

    More options are great I suppose, but as a gem-xer I don’t get the modern revolt against the condom. Modern condoms are pretty damn thin / good and are a form of male birth control with bonus of very good disease prevention, have next to no side effects, and minimize messes too.

    • @TheGrandNagus@lemmy.world
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      251 year ago

      All true, but they also feel awful, sometimes painfully tight, and are total erection killers. I use them, but I hate using them.

      • @NOPper@lemmy.world
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        71 year ago

        It’s the pause in the flow of things to go get one and put it on plus difficulty finding the right size. Used em my entire life until my wife had an IUD put in. After a few ears she had it removed and going back to condoms was not super fun for either of us.

        On the bright side for me, a vasectomy solved all these issues and was totally worth the minimal process to get it. This solution sounds like a dream honestly.

    • @trebuchet@lemmy.ml
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      131 year ago

      Modern?

      Has it increased in some way over time? I think men not wanting to wear condoms because of how they feel is a tale as old as the condom itself.

      • @Imgonnatrythis@sh.itjust.works
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        11 year ago

        I think for those that have grown up with porn in their palms it is different yes. Admittedly that’s my impression and that of my peer group. I’m not aware of data on the matter.

    • setVeryLoud(true);
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      51 year ago

      IMO for anyone in a stable monoamorous relationship, the IUD is the superior option, as long as the female partner is a good fit for it and doesn’t have complications from it.

      • gordon
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        21 year ago

        My wife had significant issues with hers, including basically never-ending spotting and occasional surprise periods, cramps, mood issues, etc. She had it removed after 2 years.

        I’m thinking a vasectomy is the next thing, but it isn’t covered on my insurance and finding a doctor is intimidating.

    • @Ithi@lemmy.ca
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      11 year ago

      There’s no harm in condom + anything else considering all the horror stories of condoms accidentally/intentionally not working.

      This gives another option that sounds pretty easy and not very invasive for anyone.

      • @Imgonnatrythis@sh.itjust.works
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        1 year ago

        There are horror stories for everything. There are also statistics. If you prefer horror stories to the latter there is nothing you shouldn’t fear.

  • Chris
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    141 year ago

    These reversable, injectable, male contraceptives have been promised for at least 5 years, when will they come to market?

  • @daniskarma@lemmy.world
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    131 year ago

    I’ve been seeing promises about a new male contraceptive for more than a decade now. They never seem to hit the shelves form some reason.

    • newcockroach
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      1 year ago

      TSA:what are you hiding sir.
      Me:nothing : o.
      TSA:(Boink! Boink!)sir stop resisting! This is standard procedure.(Boink! Boink!)

  • @inclementimmigrant@lemmy.world
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    81 year ago

    RISUG has been in promised for what, nearly a decade now? This has been the FSD/Star Citizen of the male contraceptive world, always right around the corner.

  • @RedAggroBest@lemmy.world
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    71 year ago

    Contraline’s method involves making a small piercing in the scrotum and using a handheld injector to push the hydrogel through a catheter that’s connected to the vas deferens. The catheter is then taken out, and the puncture heals on its own.

    That sounds like a bit more than just an injection. Not quite like going in for a flu shot to the nuts